Technology Process of 1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-1-(phenylsulfonyl)-
There total 5 articles about 1H-Pyrrolo[2,3-b]pyridine-5-carboxaldehyde, 4-chloro-1-(phenylsulfonyl)- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.333333h;
benzenesulfonyl chloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
1.2: 20 h / 25 °C
2.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 8 h / -75 - -60 °C / Inert atmosphere; Large scale
2.2: 2 h / -75 - -65 °C / Large scale
3.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 0 - 5 °C / Large scale
3.2: 1 h / 10 °C / Large scale
With
sec.-butyllithium; sodium hydride; caesium carbonate;
In
tetrahydrofuran; cyclohexane; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 8 h / 0 - 10 °C / Large scale
2.1: methanesulfonyl chloride / N,N-dimethyl-formamide / 2 h / 50 - 90 °C / Large scale
3.1: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere
3.2: 20 h / 25 °C
4.1: sec.-butyllithium / cyclohexane; tetrahydrofuran / 8 h / -75 - -60 °C / Inert atmosphere; Large scale
4.2: 2 h / -75 - -65 °C / Large scale
5.1: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 0 - 5 °C / Large scale
5.2: 1 h / 10 °C / Large scale
With
sec.-butyllithium; sodium hydride; caesium carbonate; methanesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; mineral oil;
