2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride

Base Information

• Chemical Name: 2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride
• CAS No.: 358352-95-1
• Molecular Formula: C₈H₃ClF₄O₂
• Molecular Weight: 242.557
• Mol file: 358352-95-1.mol

Synonyms:2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride

Chemical Property of 2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride

There total 2 articles about 2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2,3,4,5-tetrafluoro-6-methoxybenzoic acid (38512-77-5) → 2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride (358352-95-1)

Guidance literature:

With phosphorus pentachloride;

DOI:10.1016/S0022-1139(01)00346-3

Reference yield:

methanol (67-56-1) + Pentafluorobenzoic acid (602-94-8) → pentafluorobenzoylchloride (2251-50-5) + 2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride (358352-95-1)

Guidance literature:

methanol; With iodine; magnesium; In toluene; Reflux;

Pentafluorobenzoic acid; In toluene; for 2h; Reflux;

With phosphorus pentachloride; In toluene; at 70 ℃; for 1h; Reagent/catalyst;

DOI:10.1016/j.bmcl.2016.03.107

Reference yield: 98.0%

2-Methoxy-3,4,5,6-tetrafluorobenzoyl chloride (358352-95-1) → 2,3,4,5-tetrafluoro-6-methoxybenzoic acid (38512-77-5)

Guidance literature:

With sodium hydrogencarbonate; In water; at 20 ℃; for 1h;

DOI:10.1023/A:1013479323203

upstream raw materials:

2,3,4,5-tetrafluoro-6-methoxybenzoic acid

methanol

Pentafluorobenzoic acid

Downstream raw materials:

Ethyl 2-(2-methoxy-3,4,5,6-tetrafluorobenzoyl)-3-oxobutanoate

ethyl 2-(2-methoxy-3,4,5,6-tetrafluorobenzoyl)-3-oxobutanoate

2,3,4,5-tetrafluoro-6-methoxybenzoic acid

N-(pentafluorophenyl)-3,4,5,6-tetrafluoro-2-methoxybenzamide

Refernces

• 1、 Shchegol'Kov, Evgeny V.,Shchur, Irina V.,Burgart, Yanina V.,Saloutin, Victor I.,Solodnikov, Sergey Yu.,Krasnykh, Olga P.,Kravchenko, Marionella A.. "A convenient and efficient approach to polyfluorosalicylic acids and their tuberculostatic activity". supporting information. p. 2455 - 2458. Retrieved 2016/07/07.
• 2、 Kisil',Burgart,Saloutin. "New fluoroaryl-containing β,β′-dioxoesters in the synthesis of fluorobenzopyran-2(4)-ones". . p. 1455 - 1462. Retrieved 2007/10/03.