4-Chloro-1-naphthol

Base Information

• Chemical Name: 4-Chloro-1-naphthol
• CAS No.: 604-44-4
• Molecular Formula: C10H7 Cl O
• Molecular Weight: 178.618
• Hs Code.: 2908199090
• European Community (EC) Number: 210-068-5
• NSC Number: 44345
• UNII: P4NNY2FQ2A
• DSSTox Substance ID: DTXSID3060536
• Nikkaji Number: J95.406C
• Wikidata: Q22668708
• ChEMBL ID: CHEMBL3310663
• Mol file: 604-44-4.mol

Synonyms:4-chloro-1-naphthalenol;4-chloro-1-naphthol

Chemical Property of 4-Chloro-1-naphthol

Chemical Property:

• Appearance/Colour: Off white to tan crystals
• Vapor Pressure: 7.74E-05mmHg at 25°C
• Melting Point: 118-121 °C(lit.)
• Refractive Index: 1.4575 (estimate)
• Boiling Point: 332.1oC at 760 mmHg
• PKA: 9.11±0.40(Predicted)
• Flash Point: 73°C
• PSA: 20.23000
• Density: 1.333g/cm3
• LogP: 3.19880
• Storage Temp.: 2-8°C
• Solubility.: methanol: 50 mg/mL, clear, colorless to very faintly yellow
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 178.0185425
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-1-naphthol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 36/37/38-39/23/24/25-20/21/22
• Safety Statements: 26-36-45-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Naphthols
• Canonical SMILES: C1=CC=C2C(=C1)C(=CC=C2Cl)O
• Uses: 4-Chloro-1-naphthol has been used to visualize protein bands in western blotting. It has also been used in staining polyvinylidene fluoride (PVDF) membrane by Nakane method. Suitable for visualizing protein-peroxidase conjugates in western blotting.

Technology Process of 4-Chloro-1-naphthol

There total 29 articles about 4-Chloro-1-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

α-naphthol (90-15-3) → 4-chloronaphthalen-1-ol (604-44-4) + 2-chloro-1-naphthol (606-40-6)

Guidance literature:

With sulfuryl dichloride; In 1,2-dichloro-ethane; at 0 - 25 ℃; for 7h;

DOI:10.1002/asia.201000804

Reference yield: 44.0%

α-naphthol (90-15-3) → 4-chloronaphthalen-1-ol (604-44-4) + 2,4-dichloronaphthol (2050-76-2) + 2-chloro-1-naphthol (606-40-6)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 0 ℃; for 3.5h;

DOI:10.1002/asia.201000804

Reference yield: 40.0%

α-naphthol (90-15-3) → 4-chloronaphthalen-1-ol (604-44-4)

Guidance literature:

With sulfuryl dichloride; In chlorobenzene; at 20 - 73 ℃; for 15h;

DOI:10.1002/asia.201000804

upstream raw materials:

α-naphthol

1-chloro-4-methoxynaphthalene

pyridine hydrochloride

1-naphthyl tosylate

Downstream raw materials:

9-chloro-10-hydroxyanthracene-1,4-dione

indophenol blue

1-chloro-4-methoxynaphthalene

2-amino-6-chloro-4-(4-methylphenyl)-4H-benzo[h]chromene-3-carbonitrile

Refernces

• 1、 Dinh, Andrew N.,Maddox, Sean M.,Vaidya, Sagar D.,Saputra, Mirza A.,Nalbandian, Christopher J.,Gustafson, Jeffrey L.. "Catalyst-Controlled Regioselective Chlorination of Phenols and Anilines through a Lewis Basic Selenoether Catalyst". . p. 13895 - 13905. Retrieved 2020/11/03.
• 2、 Xiong, Xiaodong,Yeung, Ying-Yeung. "Ammonium Salt-Catalyzed Highly Practical Ortho-Selective Monohalogenation and Phenylselenation of Phenols: Scope and Applications". . p. 4033 - 4043. Retrieved 2018/05/22.