13-Methoxydihydronitidine

Base Information

• Chemical Name: 13-Methoxydihydronitidine
• CAS No.: 41349-33-1
• Molecular Formula: C22H21NO5
• Molecular Weight: 379.4058
• NSC Number: 166741,147789,146396
• ChEMBL ID: CHEMBL488612
• Mol file: 41349-33-1.mol

Synonyms:13-Methoxydihydronitidine;Nitidine pseudomethanolate;5,6-Dihydro-6-methoxynitidine;Nitidine, methoxydihydro-;41349-33-1;NSC146396;NSC 146396;BRN 0582405;(1,3)Benzodioxolo(5,6-c)phenanthridine, 12,13-dihydro-12-methyl-2,3,13-trimethoxy-;12,13-Dihydro-12-methyl-2,3,13-trimethoxy-(1,3)benzodioxolo(5,6-c)phenanthridine;(1,3)Benzodioxolo(5,6-c)phenanthridine, 12,13-dihydro-2,3,13-trimethoxy-12-methyl-;NSC-146396;NITIDINE, METHOXYDIHYDRO;[1,6-c]phenanthridine, 12,13-dihydro-2,3,13-trimethoxy-12-methyl-;[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-2,3,13-trimethoxy-12-methyl-;2,3,13-trimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine;Neuro_000080;CHEMBL488612;SCHEMBL13103359;NSC147789;NSC166741;NSC-147789;NSC-166741;2,3,13-Trimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine;LS-34779;NCI60_000994;CN1C(OC)c2cc(OC)c(OC)cc2c3ccc4cc5OCOc5cc4c13

Chemical Property of 13-Methoxydihydronitidine

Chemical Property:

• Vapor Pressure: 7.25E-13mmHg at 25°C
• Boiling Point: 566.8°Cat760mmHg
• Flash Point: 168°C
• Density: 1.36g/cm³
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 379.14197277
• Heavy Atom Count: 28
• Complexity: 561

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C(C2=CC(=C(C=C2C3=C1C4=CC5=C(C=C4C=C3)OCO5)OC)OC)OC

Technology Process of 13-Methoxydihydronitidine

There total 10 articles about 13-Methoxydihydronitidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methanol (67-56-1) + nitidine chloride (13063-04-2) → 5,6-dihydro-6-methoxynitidine (41349-33-1)

Guidance literature:

nitidine chloride; With ammonium hydroxide; at 20 ℃; for 0.5h;

methanol; In ethyl acetate;

DOI:10.1007/s11164-019-03977-z

Reference yield:

nornitidine (18034-03-2) → 5,6-dihydro-6-methoxynitidine (41349-33-1)

Guidance literature:

Multi-step reaction with 2 steps

1: xylene; nitrobenzene

2: aq. NH₃

With ammonium hydroxide; In nitrobenzene; xylene;

Reference yield:

2,3-dimethoxy-4b,5,6,11b-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine (41303-71-3) → 5,6-dihydro-6-methoxynitidine (41349-33-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfur

2: xylene; nitrobenzene

3: aq. NH₃

With ammonium hydroxide; sulfur; In nitrobenzene; xylene;

upstream raw materials:

Nitidine methyl sulfate

nornitidine

2,3-dimethoxy-4b,5,6,11b-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c]phenanthridine

N-[6-(3,4-dimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxol-5-yl]-formamide