ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

Base Information

Chemical Name:ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate
CAS No.:1436389-46-6
Molecular Formula:C₂₅H₃₁F₂NO₅
Molecular Weight:463.522
Hs Code.:

Synonyms:ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

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Chemical Property of ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

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Technology Process of ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

There total 4 articles about ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1394928-30-3
ethyl difluoro(4-hydroxyphenyl)acetate

: 244059-08-3
tert-butyl N-(3-hydroxy-3-phenylpropyl)-N-methylcarbamate

: 1436389-46-6
ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In diethyl ether; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol4009377

Reference yield:

: 540-38-5
p-Iodophenol

: 1436389-46-6
ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: copper / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; copper; triphenylphosphine; In diethyl ether; dimethyl sulfoxide;
DOI:10.1021/ol4009377

Reference yield:

: 5053-63-4
3-amino-1-phenylpropan-1-ol

: 1436389-46-6
ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 6 h / Inert atmosphere; Reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In methanol; diethyl ether;
DOI:10.1021/ol4009377