(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

Base Information

Chemical Name:(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid
CAS No.:1436389-35-3
Molecular Formula:C₂₃H₂₇F₂NO₅
Molecular Weight:435.468
Hs Code.:

Synonyms:(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

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Chemical Property of (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

Chemical Property:

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Technology Process of (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

There total 6 articles about (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1436389-46-6
ethyl (4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetate

: 1436389-35-3
(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

Guidance literature:: With potassium carbonate; In methanol; water; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol4009377

Reference yield:

: 540-38-5
p-Iodophenol

: 1436389-35-3
(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: copper / dimethyl sulfoxide / 12 h / 60 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; copper; potassium carbonate; triphenylphosphine; In methanol; diethyl ether; water; dimethyl sulfoxide;
DOI:10.1021/ol4009377

Reference yield:

: 5053-63-4
3-amino-1-phenylpropan-1-ol

: 1436389-35-3
(4-{3-[(tert-butoxycarbonyl)(methyl)amino]-1-phenylpropoxy}phenyl)(difluoro)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / methanol / 6 h / Inert atmosphere; Reflux

2: di-isopropyl azodicarboxylate; triphenylphosphine / diethyl ether / 1 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / methanol; water / 2 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; triphenylphosphine; In methanol; diethyl ether; water;
DOI:10.1021/ol4009377