Technology Process of methyl 2-((2S,3S,4R)-4-acetoxy-1-(2-fluoro-4-hydroxyphenyl)-3-methylpyrrolidin-2-yl)acetate
There total 12 articles about methyl 2-((2S,3S,4R)-4-acetoxy-1-(2-fluoro-4-hydroxyphenyl)-3-methylpyrrolidin-2-yl)acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 2-((2S,3S,4R)-1-(2-fluoro-4-hydroxyphenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetate; acetic anhydride;
With
pyridine; dmap;
In
dichloromethane;
at 20 ℃;
for 1.5h;
With
ammonium acetate;
In
methanol; water;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C
1.2: 4 h / 65 °C
2.1: hydrogenchloride / methanol; dichloromethane; acetic acid methyl ester / 21 h / 40 °C
3.1: boron dimethyl-trifluoro sulphide / dichloromethane / 7 h / 0 °C
3.2: 4.33 h / 0 - 20 °C
4.1: dmap; pyridine / dichloromethane / 1.5 h / 20 °C
4.2: 48 h / 20 °C
With
pyridine; hydrogenchloride; dmap; boron dimethyl-trifluoro sulphide; methanesulfonyl chloride; triethylamine;
In
methanol; dichloromethane; acetic acid methyl ester;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; copper(l) iodide / butan-1-ol / 24 h / 90 °C / Inert atmosphere
2.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1 h / 0 °C
2.2: 4 h / 65 °C
3.1: hydrogenchloride / methanol; dichloromethane; acetic acid methyl ester / 21 h / 40 °C
4.1: boron dimethyl-trifluoro sulphide / dichloromethane / 7 h / 0 °C
4.2: 4.33 h / 0 - 20 °C
5.1: dmap; pyridine / dichloromethane / 1.5 h / 20 °C
5.2: 48 h / 20 °C
With
pyridine; hydrogenchloride; dmap; copper(l) iodide; boron dimethyl-trifluoro sulphide; methanesulfonyl chloride; triethylamine; sodium hydroxide;
In
methanol; dichloromethane; acetic acid methyl ester; butan-1-ol;
