(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide

Base Information

• Chemical Name: (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide
• CAS No.: 329010-42-6
• Molecular Formula: C₂₁H₂₂ClNO₂S
• Molecular Weight: 387.93
• Mol file: 329010-42-6.mol

Synonyms:(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide

Chemical Property of (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide

There total 3 articles about (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

1-bromo-4-butene (5162-44-7) + (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide (204857-48-7) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide (329010-42-6)

Guidance literature:

(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide; With sodium hydride; In tetrahydrofuran;

1-bromo-4-butene; In tetrahydrofuran; Further stages.; Heating;

DOI:10.1021/ol006863e

Reference yield:

3-phenyl-propenal (104-55-2) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide (329010-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C

1.2: 99 percent / tetrahydrofuran / 18 h / -78 - 20 °C

2.1: NaH / tetrahydrofuran

2.2: 44 percent / tetrahydrofuran / Heating

With potassium tert-butylate; sodium hydride; In tetrahydrofuran;

DOI:10.1021/ol006863e

Reference yield:

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide (329010-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: t-BuOK / tetrahydrofuran / 1 h / -78 °C

1.2: 99 percent / tetrahydrofuran / 18 h / -78 - 20 °C

2.1: NaH / tetrahydrofuran

2.2: 44 percent / tetrahydrofuran / Heating

With potassium tert-butylate; sodium hydride; In tetrahydrofuran;

DOI:10.1021/ol006863e

upstream raw materials:

1-bromo-4-butene

(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

3-phenyl-propenal

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide