(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

Base Information

• Chemical Name: (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide
• CAS No.: 204857-48-7
• Molecular Formula: C₁₇H₁₆ClNO₂S
• Molecular Weight: 333.839
• Mol file: 204857-48-7.mol

Synonyms:(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

Chemical Property of (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide

There total 4 articles about (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-phenyl-propenal (104-55-2) + N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide (204857-48-7)

Guidance literature:

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 1h;

3-phenyl-propenal; In tetrahydrofuran; at -78 - 20 ℃; for 18h; Further stages.;

DOI:10.1021/ol006863e

Reference yield: 78.0%

(E)-3-phenylpropenal (14371-10-9) + N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide (204857-35-2) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide (204857-48-7)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; 1.) -78 deg C, 1 h, 2.) -78 to 20 deg C, 18 h;

DOI:10.1055/s-1998-1609

Reference yield:

N-(4-chloro-benzyl)-methanesulfonamide (42060-30-0) → (1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid 4-chloro-benzylamide (204857-48-7)

Guidance literature:

Multi-step reaction with 2 steps

1: DMAP / CH₂Cl₂

2: 78 percent / t-BuOK / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) -78 to 20 deg C, 18 h

With dmap; potassium tert-butylate; In tetrahydrofuran; dichloromethane;

DOI:10.1055/s-1998-1609

upstream raw materials:

(E)-3-phenylpropenal

N-(tert-butoxycarbonyl)-N-(4-chlorobenzyl)-methanesulfonamide

3-phenyl-propenal

N-(4-chloro-benzyl)-methanesulfonamide

Downstream raw materials:

(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid allyl-(4-chloro-benzyl)-amide

(1E,3E)-4-Phenyl-buta-1,3-diene-1-sulfonic acid but-3-enyl-(4-chloro-benzyl)-amide