(S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Base Information

Chemical Name:(S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide
CAS No.:1380585-84-1
Molecular Formula:C₂₂H₂₉BrN₂O₂S
Molecular Weight:465.454
Hs Code.:

Synonyms:(S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Suppliers and Price of (S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

There total 6 articles about (S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1380585-88-5
(S)-N-benzyl-N-(2-bromophenyl)-4-(1,1-dimethylethylsulfinamido)butanamide

: 74-88-4
methyl iodide

: 1380585-84-1
(S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Guidance literature:: (S)-N-benzyl-N-(2-bromophenyl)-4-(1,1-dimethylethylsulfinamido)butanamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; mineral oil; at 20 ℃; for 15h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ol3012056

Reference yield:

: 1380585-87-4
N-benzyl-N-(2-bromophenyl)-4-oxobutanamide

: 1380585-84-1
(S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydrogensulfate / toluene / 3 h / 45 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 15 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hydrogensulfate; sodium hydride; In tetrahydrofuran; methanol; toluene; mineral oil;
DOI:10.1021/ol3012056

Reference yield:

: 1380585-86-3
N-benzyl-N-(2-bromophenyl)-4-hydroxybutanamide

: 1380585-84-1
(S)-N-benzyl-N-(2-bromophenyl)-4-(N,2-dimethylpropan-2-ylsulfinamido)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: Dess-Martin periodane / dichloromethane / 6 h / 20 °C / Inert atmosphere

2.1: potassium hydrogensulfate / toluene / 3 h / 45 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 4.5 h / 0 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

4.2: 15 h / 20 °C / Inert atmosphere

With sodium tetrahydroborate; potassium hydrogensulfate; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; toluene; mineral oil;
DOI:10.1021/ol3012056