(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

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Chemical Name:(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate
CAS No.:1005210-14-9
Molecular Formula:BF₄*C₃₀H₃₆N₃OSi
Molecular Weight:569.525
Hs Code.:

Synonyms:(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

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Chemical Property of (S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

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Technology Process of (S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

There total 7 articles about (S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 420-37-1
trimethoxonium tetrafluoroborate

: 100-63-0
phenylhydrazine

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

: 1005210-14-9
(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

Guidance literature:: trimethoxonium tetrafluoroborate; (-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one; In dichloromethane; at 20 ℃;

phenylhydrazine; In dichloromethane; at 20 ℃;

With trimethyl orthoformate; at 80 ℃; Further stages.;
DOI:10.1016/j.tetasy.2008.05.017

Reference yield: 62.0%

: 122-51-0
orthoformic acid triethyl ester

: 100-63-0
phenylhydrazine

: 249617-46-7
(-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one

: 1005210-14-9
(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

Guidance literature:: (-)-(S)-[Diphenyl(tert-butyldimethylsilyloxy)methyl]pyrrolidin-2-one; With trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃;

phenylhydrazine; In dichloromethane; at 20 ℃; for 24h;

orthoformic acid triethyl ester; In methanol; at 120 ℃; for 24h; Further stages.;
DOI:10.1021/ol702759b

Reference yield:

: 4931-66-2
methyl (S)-pyroglutamate

: 1005210-14-9
(S)-5-{[(tert-butyldimethylsilyl)oxy]diphenylmethyl}-2-phenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 1.25 h / -78 - 0 °C

1.2: Cooling with ice

2.1: triethylamine / dichloromethane / 7 h / 0 - 20 °C

3.1: trimethoxonium tetrafluoroborate / dichloromethane / 16 h

3.2: 24 h

3.3: 16 h / 100 °C

With trimethoxonium tetrafluoroborate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tetasy.2011.04.001