3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Base Information

Chemical Name:3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester
CAS No.:1071179-35-5
Molecular Formula:C₂₀H₃₈O₃Si
Molecular Weight:354.605
Hs Code.:

Synonyms:3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

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Chemical Property of 3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

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Technology Process of 3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

There total 7 articles about 3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1071178-92-1
trifluoromethanesulfonic acid 3-(3-(tert-butyldimethylsilanyloxy)propyl)-3,6,6-trimethylcyclohex-1-enyl ester

: 1071179-35-5
3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 40 ℃; for 12h;
DOI:10.1002/chem.200800930

Reference yield:

: 1071179-31-1
3-(3-(tert-butyldimethylsilyloxy)propyl)-6-methylcyclohex-2-enone

: 1071179-35-5
3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

2.2: 1 h / -20 °C / Inert atmosphere

2.3: -20 - 20 °C / Inert atmosphere

3.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01086c

Reference yield:

: 1071178-87-4
3-(3-(tert-butyldimethylsilanyloxy)propyl)-6,6-dimethylcyclohex-2-enone

: 1071179-35-5
3-(3-(tert-butyldimethylsilanyloxy)-propyl)-3,6,6-trimethylcyclohex-1-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 1 h / -20 °C / Inert atmosphere

1.3: -20 - 20 °C / Inert atmosphere

2.1: palladium diacetate; triethylamine; triphenylphosphine / N,N-dimethyl-formamide / 20 °C

With copper(l) iodide; palladium diacetate; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0ob01086c