2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Base Information

Chemical Name:2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one
CAS No.:108442-49-5
Molecular Formula:C₁₆H₁₅FN₄O
Molecular Weight:298.32
Hs Code.:

Synonyms:2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Suppliers and Price of 2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

There total 4 articles about 2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 108442-16-6
2-(2-fluorophenyl)-7,8,9,10-tetrahydro-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)one

: 74-88-4
methyl iodide

: 108442-49-5
2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; at 50 - 80 ℃; for 1h;
DOI:10.1021/jm00113a032

Reference yield:

: 646-20-8
pimelonitrile

: 108442-49-5
2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: KH / tetrahydrofuran

2: NaOEt / ethanol / 2 h / 110 °C

3: 55 percent / tri-n-propylamine / 2-methoxy-ethanol / 16 h / Heating

4: 54 percent / NaOH / dimethylsulfoxide / 1 h / 50 - 80 °C

With tri-n-propylamine; sodium hydroxide; sodium ethanolate; potassium hydride; In tetrahydrofuran; ethanol; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00113a032

Reference yield:

: 15595-71-8
2-aminocyclohex-1-enecarbonitrile

: 108442-49-5
2-(2-fluorophenyl)-6-methyl-7,8,9,10-tetrahydro[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: NaOEt / ethanol / 2 h / 110 °C

2: 55 percent / tri-n-propylamine / 2-methoxy-ethanol / 16 h / Heating

3: 54 percent / NaOH / dimethylsulfoxide / 1 h / 50 - 80 °C

With tri-n-propylamine; sodium hydroxide; sodium ethanolate; In ethanol; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00113a032