Clostebol

Base Information

• Chemical Name: Clostebol
• CAS No.: 1093-58-9
• Molecular Formula: C19H27 Cl O2
• Molecular Weight: 322.875
• European Community (EC) Number: 214-133-9
• UNII: Z7D4G976SH
• DSSTox Substance ID: DTXSID5046192
• Nikkaji Number: J7.255I
• Wikipedia: Clostebol
• Wikidata: Q422322
• NCI Thesaurus Code: C77306
• Metabolomics Workbench ID: 35324
• ChEMBL ID: CHEMBL2106571
• Mol file: 1093-58-9.mol

Synonyms:4-chloro-delta-4-androstene-3alpha-ol-17-one;clostebol

Chemical Property of Clostebol

Chemical Property:

• Vapor Pressure: 6.3E-10mmHg at 25°C
• Melting Point: 188-190°
• Refractive Index: 1.567
• Boiling Point: 448.4 °C at 760 mmHg
• PKA: 14.99±0.70(Predicted)
• Flash Point: 225 °C
• PSA: 37.30000
• Density: 1.2g/cm³
• LogP: 4.44570
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 322.1699578
• Heavy Atom Count: 22
• Complexity: 554

Purity/Quality:

99% ^*data from raw suppliers

Clostebol ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 40
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2O)CCC4=C(C(=O)CCC34C)Cl
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C(C(=O)CC[C@]34C)Cl
• Description: Clostebol (Item No. 21168) is an analytical reference standard that is categorized as an androgenic anabolic steroid. Clostebol is a chlorinated form of testosterone (Item Nos. 15645 | ISO60154) that has been used as an athletic performance enhancer and to fatten cattle. It is also detectible in urine. Formulations containing clostebol have been used to treat osteoporosis, anorexia, and certain types of liver disease. Clostebol is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.
• Uses: Clostebol is an anabolic steroid. This is a controlled substance.

Technology Process of Clostebol

There total 6 articles about Clostebol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

clostebol acetate (855-19-6) → clostebol (1093-58-9)

Guidance literature:

With hydrogenchloride; In acetone; at 75 ℃; for 15h;

DOI:10.1021/jf9906984

Reference yield:

17β-hydroxy-4β,5-epoxy-5β-androstan-3-one (2189-83-5) → clostebol (1093-58-9)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/jo01118a028

Reference yield:

testosterone (58-22-0) → clostebol (1093-58-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous hydrogen peroxide; aqueous methanol. NaOH-solution

2: HCl

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide;

DOI:10.1021/jo01118a028

upstream raw materials:

17β-hydroxy-4β,5-epoxy-5β-androstan-3-one

clostebol acetate

testosterone

Downstream raw materials:

4-Chlor-testosteron-17-nitrat

4-chloro-17β-phenylacetoxy-androst-4-en-3-one

4-chloro-17β-(4-methoxy-trans-cinnamoyloxy)-androst-4-en-3-one

Refernces

• 1、 Crabbe,Van Peteghem,Salden,Kohen. "Influence of the hapten conjugation site on the characteristics of antibodies generated against metabolites of clostebol acetate". . p. 3633 - 3638. Retrieved 2000.