4-METHOXYBENZALDEHYDE AZINE

Base Information

• Chemical Name: 4-METHOXYBENZALDEHYDE AZINE
• CAS No.: 2299-73-2
• Molecular Formula: C₁₆H₁₆N₂O₂
• Molecular Weight: 268.315
• Hs Code.: 2928000090
• European Community (EC) Number: 636-599-6
• Mol file: 2299-73-2.mol

Synonyms:Benzaldehyde,4-methoxy-, [(4-methoxyphenyl)methylene]hydrazone (9CI); p-Anisaldehyde, azine (6CI,7CI,8CI);4,4'-Dimethoxybenzaldazine; 4,4'-Dimethoxybenzylideneazine;4-Methoxybenzalazine; 4-Methoxybenzaldehyde[(4-methoxyphenyl)methylene]hydrazone; 4-Methoxybenzaldehyde azine;Anisalazine; Anisaldazine; NSC 1987; p-Anisalazine; p-Anisaldazine; p-Methoxybenzaldazine;p-Methoxybenzaldehyde azine

Chemical Property of 4-METHOXYBENZALDEHYDE AZINE

Chemical Property:

• Melting Point: 167 °C
• Boiling Point: 390.6°Cat760mmHg
• PKA: 6.74±0.50(Predicted)
• Flash Point: 153.7°C
• PSA: 43.18000
• Density: 1.05g/cm³
• LogP: 3.15680
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 268.121177757
• Heavy Atom Count: 20
• Complexity: 282

Purity/Quality:

99% ^*data from raw suppliers

1,2-Bis(4-methoxybenzylidene)hydrazine 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=NN=CC2=CC=C(C=C2)OC
• Isomeric SMILES: COC1=CC=C(C=C1)/C=N/N=C\C2=CC=C(C=C2)OC

Technology Process of 4-METHOXYBENZALDEHYDE AZINE

There total 57 articles about 4-METHOXYBENZALDEHYDE AZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methoxy-benzaldehyde (123-11-5) → N,N-bis(4-methoxybenzylidene)hydrazine (2299-73-2,41097-47-6)

Guidance literature:

With bismuth(III) chloride; hydrazine; In water; at 20 ℃; for 0.0166667h; Sonication; Green chemistry;

DOI:10.1016/j.ultsonch.2013.12.011

Reference yield: 91.0%

4-Methoxybenzyl alcohol (105-13-5) → N,N-bis(4-methoxybenzylidene)hydrazine (2299-73-2,41097-47-6)

Guidance literature:

With hydrazine hydrate; [RuHCl(CO)(2,6-bis[(di-tertbutylphosphino)methyl]pyridine)]; potassium tert-butylate; In toluene; at 130 ℃; for 50h; Reagent/catalyst; Molecular sieve; Reflux; Schlenk technique;

DOI:10.1021/acscatal.6b02946

Reference yield: 90.0%

5-(4-methoxybenzylidene)barbituric acid (49546-71-6) → N,N-bis(4-methoxybenzylidene)hydrazine (2299-73-2,41097-47-6)

Guidance literature:

With hydrazine hydrate; In methanol; Reflux;

upstream raw materials:

4-methoxybenzaldehyde semicarbazone

(E)-1-methoxy-4-(2-nitrovinyl)benzene

4-methoxy-benzaldehyde

4-methoxybenzonitrile

Downstream raw materials:

3,7-bis-(4-methoxy-phenyl)-tetrahydro-pyrazolo[1,2-a]pyrazole-1,2,5,6-tetracarboxylic acid-1,2;5,6-dianhydride

3-(4-methoxy-benzylideneamino)-2-(4-methoxy-phenyl)-thiazolidin-4-one

(2-(4-methoxyphenyl)methylene)hydrazolyl-1,3-thiazolidin-4-one

4-methoxy-benzaldehyde [5-(4-methoxy-benzylidene)-4-oxo-thiazolidin-2-ylidene]-hydrazone

Refernces

• 1、 Gunanathan, Chidambaram,Pradhan, Subham,Thiyagarajan, Subramanian. "Ruthenium(ii)-catalysed 1,2-selective hydroboration of aldazines". supporting information. p. 7147 - 7151. Retrieved 2021/08/30.
• 2、 El-Metwally, S. A.,Regal, M. K. A.,Shaban, S. S.. "Synthesis and Antimicrobial Activity of Some New Coumarin and Dicoumarol Derivatives". . p. 438 - 447. Retrieved 2020/06/30.