6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

Base Information

Chemical Name:6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid
CAS No.:1444000-02-5
Molecular Formula:C₂₆H₃₀N₂O₁₁
Molecular Weight:546.531
Hs Code.:

Synonyms:6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

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Chemical Property of 6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

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Technology Process of 6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

There total 4 articles about 6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1444000-04-7
3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester

: 1444000-02-5
6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

Guidance literature:: 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester; With sodium methylate; In methanol; at 0 ℃; Inert atmosphere;

With water; In methanol; at 20 ℃;
DOI:10.1016/j.ejmech.2013.03.062

Reference yield:

: 1044870-39-4
2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

: 2616-64-0
UDP-glucuronic acid

: 1444000-02-5
6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

Guidance literature:: With glucose-6-phosphate dehydrogenase; D-glucose 6-phosphate; nicotinamide adenine dinucleotide phosphate; magnesium chloride; In aq. phosphate buffer; dimethyl sulfoxide; at 37 ℃; for 24h; pH=7.4; Concentration; Reagent/catalyst; Time; Enzymatic reaction;
DOI:10.1016/j.ejmech.2013.03.062

Reference yield:

: 1444000-03-6
2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

: 1444000-02-5
6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver(l) oxide / dichloromethane / 72 h / 20 °C / Molecular sieve; Inert atmosphere; Darkness

2.1: sodium methylate / methanol / 0 °C / Inert atmosphere

2.2: 20 °C

With sodium methylate; silver(l) oxide; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.062