2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

Base Information

Chemical Name:2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester
CAS No.:1444000-03-6
Molecular Formula:C₂₆H₃₂N₂O₇
Molecular Weight:484.549
Hs Code.:

Synonyms:2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

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Chemical Property of 2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

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Technology Process of 2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

There total 1 articles about 2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 18997-19-8
Chloromethyl pivalate

: 1044870-39-4
2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

: 1444000-03-6
2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

Guidance literature:: 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Inert atmosphere;

Chloromethyl pivalate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2013.03.062

Reference yield: 34.0%

: 1444000-03-6
2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

: 21085-72-3
1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

: 1444000-04-7
3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester

Guidance literature:: With silver(l) oxide; In dichloromethane; at 20 ℃; for 72h; Molecular sieve; Inert atmosphere; Darkness;
DOI:10.1016/j.ejmech.2013.03.062

Reference yield:

: 1444000-03-6
2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

: 1444000-02-5
6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: silver(l) oxide / dichloromethane / 72 h / 20 °C / Molecular sieve; Inert atmosphere; Darkness

2.1: sodium methylate / methanol / 0 °C / Inert atmosphere

2.2: 20 °C

With sodium methylate; silver(l) oxide; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.062