3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester

Base Information

• Chemical Name: 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester
• CAS No.: 1444000-04-7
• Molecular Formula: C₃₉H₄₈N₂O₁₆
• Molecular Weight: 800.814
• Mol file: 1444000-04-7.mol

Synonyms:3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester

Chemical Property of 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester

There total 3 articles about 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester (1444000-03-6) + 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester (21085-72-3) → 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester (1444000-04-7)

Guidance literature:

With silver(l) oxide; In dichloromethane; at 20 ℃; for 72h; Molecular sieve; Inert atmosphere; Darkness;

DOI:10.1016/j.ejmech.2013.03.062

Reference yield:

Chloromethyl pivalate (18997-19-8) → 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester (1444000-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: silver(l) oxide / dichloromethane / 72 h / 20 °C / Molecular sieve; Inert atmosphere; Darkness

With sodium hydride; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.ejmech.2013.03.062

Reference yield:

2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one (1044870-39-4) → 3,4,5-triacetoxy-6-(2-(4-(3-(2,2-dimethylpropionyloxymethyl)-5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)tetrahydropyran-2-carboxylic acid methyl ester (1444000-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: silver(l) oxide / dichloromethane / 72 h / 20 °C / Molecular sieve; Inert atmosphere; Darkness

With sodium hydride; silver(l) oxide; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1016/j.ejmech.2013.03.062

upstream raw materials:

Chloromethyl pivalate

2,2-dimethylpropionic acid 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-4-oxo-4H-quinazolin-3-ylmethyl ester

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxy-3,4-dihydroquinazoline-4-one

Downstream raw materials:

6-(2-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)-2,6-dimethylphenoxy)ethoxy)-3,4,5-trihydroxytetrahydropyran-2-carboxylic acid