(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

Base Information

Chemical Name:(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid
CAS No.:1279038-40-2
Molecular Formula:C₂₁H₂₀FN₃O₄
Molecular Weight:397.406
Hs Code.:

Synonyms:(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

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Chemical Property of (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

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Technology Process of (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

There total 11 articles about (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2924-15-4
(2-fluorophenyl)hydrazine hydrochloride

: 1279038-40-2
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / water / 2.42 h

2.1: thionyl chloride / 4 h / 20 °C

3.1: potassium carbonate / water; 4-methyl-2-pentanone / 2.5 h / 20 °C

4.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

4.2: pH 3

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

6.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

7.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

7.2: pH 3

With thionyl chloride; oxalyl dichloride; sulfuric acid; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; water; 4-methyl-2-pentanone;

Reference yield:

: 1246555-84-9
methyl 1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate

: 1279038-40-2
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / water; 4-methyl-2-pentanone / 2.5 h / 20 °C

2.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

2.2: pH 3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

4.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

5.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

5.2: pH 3

With oxalyl dichloride; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; water; 4-methyl-2-pentanone;

Reference yield:

: 1318789-61-5
1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester

: 1279038-40-2
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

3.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

4.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

4.2: pH 3

With oxalyl dichloride; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; 4-methyl-2-pentanone;