1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester
• CAS No.: 1318789-61-5
• Molecular Formula: C₁₂H₁₁FN₂O₃
• Molecular Weight: 250.229

Synonyms:1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester

Chemical Property of 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester

There total 6 articles about 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate (1246555-84-9) + dimethyl sulfate (77-78-1) → 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester (1318789-61-5)

Guidance literature:

With potassium carbonate; In water; 4-methyl-2-pentanone; at 20 ℃; for 2.5h;

Reference yield:

methyl 1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate (1246555-84-9) + methyl iodide (74-88-4) → 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester (1318789-61-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 6h;

DOI:10.1021/jm300663n

Reference yield:

(2-fluorophenyl)hydrazine hydrochloride (2924-15-4) + dimethyl acetylenedicarboxylate (762-42-5) → 1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester (1318789-61-5)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃; for 17h;

DOI:10.1021/jm300663n

upstream raw materials:

(2-fluorophenyl)hydrazine hydrochloride

dimethyl acetylenedicarboxylate

methyl 1-(2-fluorophenyl)-5-hydroxy-1H-pyrazole-3-carboxylate

dimethyl sulfate

Downstream raw materials:

1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid

ethyl (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionate

1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl chloride

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