1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

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Chemical Name:1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide
CAS No.:1318789-20-6
Molecular Formula:C₂₆H₃₁FN₄O₃
Molecular Weight:466.556
Hs Code.:

Synonyms:1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

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Chemical Property of 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

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Technology Process of 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

There total 10 articles about 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 594-39-8
2-methyl-2-butylamine

: 1279038-40-2
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

: 1318789-20-6
1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

Guidance literature:: (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid; With N-ethylmorpholine;; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

2-methyl-2-butylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 2924-15-4
(2-fluorophenyl)hydrazine hydrochloride

: 1318789-20-6
1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / water / 2.42 h

2.1: thionyl chloride / 4 h / 20 °C

3.1: potassium carbonate / water; 4-methyl-2-pentanone / 2.5 h / 20 °C

4.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

4.2: pH 3

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

6.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

7.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

7.2: pH 3

8.1: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.17 h / 20 °C

8.2: 20 °C

With N-ethylmorpholine;; thionyl chloride; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; oxalyl dichloride; sulfuric acid; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide; 4-methyl-2-pentanone;

Reference yield:

: 1318789-61-5
1-(2-fluorophenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester

: 1318789-20-6
1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid [(S)-2-(1,1-dimethyl-propylcarbamoyl)-1-o-tolyl-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

1.2: pH 3

2.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

3.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

4.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

4.2: pH 3

5.1: O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethylmorpholine; / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 20 °C

With N-ethylmorpholine;; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; oxalyl dichloride; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; N,N-dimethyl-formamide; 4-methyl-2-pentanone;