(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

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Chemical Name:(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide
CAS No.:1279032-89-1
Molecular Formula:C₂₁H₂₁FN₄O₃
Molecular Weight:396.421
Hs Code.:

Synonyms:(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

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Chemical Property of (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

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Technology Process of (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

There total 10 articles about (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1279038-40-2
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid

: 1279032-89-1
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

Guidance literature:: (S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 16h;

With ammonia; In dichloromethane; water; for 16h;

Reference yield:

: 2924-15-4
(2-fluorophenyl)hydrazine hydrochloride

: 1279032-89-1
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / water / 2.42 h

2.1: thionyl chloride / 4 h / 20 °C

3.1: potassium carbonate / water; 4-methyl-2-pentanone / 2.5 h / 20 °C

4.1: sodium hydroxide; water / 4-methyl-2-pentanone / 16 h / 20 °C

4.2: pH 3

5.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

6.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

7.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

7.2: pH 3

8.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

8.2: 16 h

With thionyl chloride; oxalyl dichloride; sulfuric acid; water; potassium carbonate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; dichloromethane; water; 4-methyl-2-pentanone;

Reference yield:

: 1239726-11-4
1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid

: 1279032-89-1
(S)-3-{[1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carbonyl]-amino}-3-(2-methyl-phenyl)-propionic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / 2-methyltetrahydrofuran / 16 h / 0 - 20 °C

2.1: triethylamine / 2-methyltetrahydrofuran / Cooling with ice

3.1: sodium hydroxide; water / 2-methyltetrahydrofuran / 20 h / 20 - 40 °C

3.2: pH 3

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 16 h / 20 °C

4.2: 16 h

With oxalyl dichloride; water; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In 2-methyltetrahydrofuran; dichloromethane;