bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

Base Information

Chemical Name:bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol
CAS No.:241488-03-9
Molecular Formula:C₂₇H₃₀O₇
Molecular Weight:466.531
Hs Code.:

Synonyms:bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

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Chemical Property of bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

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Technology Process of bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

There total 2 articles about bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 50777-64-5
2-(2-bromophenyl)-2-methyl-1,3-dioxolane

: 4131-03-7
bis(3,4-dimethoxyphenyl)methanone

: 241488-03-9
bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

Guidance literature:: 2-(2-bromophenyl)-2-methyl-1,3-dioxolane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

bis(3,4-dimethoxyphenyl)methanone; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1055/s-1999-2762

Reference yield:

: 2142-69-0
2-bromophenyl methyl ketone

: 241488-03-9
bis-(3,4-dimethoxy-phenyl)-[2-(2-methyl-[1,3]dioxolan-2-yl)-phenyl]-methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / pTSA / toluene / 150 °C

2.1: BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 67 percent / tetrahydrofuran; hexane / -78 - 20 °C

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; toluene; 1.1: Cyclization / 2.1: Metallation / 2.2: Addition;
DOI:10.1055/s-1999-2762