5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

Base Information

Chemical Name:5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine
CAS No.:917482-62-3
Molecular Formula:C₄₅H₅₄N₂O₇Si₂
Molecular Weight:791.104
Hs Code.:

Synonyms:5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

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Technology Process of 5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

There total 5 articles about 5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 512779-26-9
5'-O-tert-butyldiphenylsilyl-5-hydroxymethyl-2',3'-O-isopropylideneuridine

: 917482-62-3
5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.tetlet.2006.09.083

Reference yield:

: 917482-61-2
2',3'-isopropylidene-5-methyl-5'-O-t-butyldiphenylsilyluridine

: 917482-62-3
5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

Guidance literature:: Multi-step reaction with 3 steps

1: N-bromosuccinimide; benzoyl peroxide / CCl₄ / Heating

2: 491 mg / NaHCO₃ / H₂O; tetrahydrofuran / 20 °C

3: 24 percent / imidazole; DMAP / dimethylformamide / 20 °C

With 1H-imidazole; dmap; N-Bromosuccinimide; sodium hydrogencarbonate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.09.083

Reference yield:

: 5-bromomethyl-1-[6-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-1H-pyrimidine-2,4-dione

: 917482-62-3
5-t-butyldiphenylsilyloxymethyl-2',3'-isopropylidene-5'-O-t-butyldiphenylsilyluridine

Guidance literature:: Multi-step reaction with 2 steps

1: 491 mg / NaHCO₃ / H₂O; tetrahydrofuran / 20 °C

2: 24 percent / imidazole; DMAP / dimethylformamide / 20 °C

With 1H-imidazole; dmap; sodium hydrogencarbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2006.09.083