5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

Base Information

Chemical Name:5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt
CAS No.:1443431-31-9
Molecular Formula:C₄H₁₁N*C₁₈H₁₈Cl₂FN₃O₄S
Molecular Weight:535.467
Hs Code.:

Synonyms:5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

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Chemical Property of 5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

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Technology Process of 5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

There total 5 articles about 5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 3984-14-3
N,N-dimethylsulfamide

: 1443431-27-3
5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid

: 109-89-7
diethylamine

: 1443431-31-9
5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

Guidance literature:: 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.25h;

N,N-dimethylsulfamide; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;

diethylamine;

Reference yield:

: 1263274-67-4
5-chloro-2-fluoro-4-methylbenzoic acid

: 1443431-31-9
5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap / tert-butyl alcohol / 18 h / 45 °C / Inert atmosphere

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C / Inert atmosphere

3.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h / 20 °C

5.2: 18 h / 20 °C / Inert atmosphere

With dmap; N-Bromosuccinimide; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;

Reference yield:

: 1443432-84-5
tert-butyl 5-chloro-4-(((5-chloro-6-cyclopropylpyridin-3-yl)oxy)methyl)-2-fluorobenzoate

: 1443431-31-9
5-chloro-4-{[(5-chloro-6-cyclopropylpyridin-3-yl)oxy]methyl}-N[(dimethylamino)sulfonyl]-2-fluorobenzamide diethylamine salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.25 h / 20 °C

2.2: 18 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane;