Technology Process of dimethyl 2-(2-(4-methoxyphenethyl)benzylidene)malonate
There total 5 articles about dimethyl 2-(2-(4-methoxyphenethyl)benzylidene)malonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrahydrofuran; pyridine; titanium tetrachloride;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1016/j.tetlet.2009.06.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triphenylphosphine / dichloromethane / 0.25 h / 0 °C
1.2: 0.55 h / 0 °C
1.3: 0.67 h / -78 °C
2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 5 h / 50 °C / Inert atmosphere
3.1: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
4.1: tetrahydrofuran; pyridine; titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere
With
tetrahydrofuran; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 10% palladium on activated carbon; hydrogen; titanium tetrachloride; triethylamine; triphenylphosphine;
In
dichloromethane; ethyl acetate;
1.1: Corey-Fuchs homologation / 1.2: Corey-Fuchs homologation / 1.3: Corey-Fuchs homologation / 2.1: Sonogashira coupling / 4.1: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007
- Guidance literature:
-
Multi-step reaction with 4 steps
1: n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 5 h / 50 °C / Inert atmosphere
3: 10% palladium on activated carbon; hydrogen / ethyl acetate / 18 h / 760.05 Torr
4: tetrahydrofuran; pyridine; titanium tetrachloride / dichloromethane / 0 - 20 °C / Inert atmosphere
With
tetrahydrofuran; pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; 10% palladium on activated carbon; hydrogen; titanium tetrachloride; triethylamine;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
2: Sonogashira coupling / 4: Knoevenagel condensation;
DOI:10.1016/j.tetlet.2009.06.007
