Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester

Base Information

• Chemical Name: Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester
• CAS No.: 183273-93-0
• Molecular Formula: C₅₃H₆₂N₄O₁₁
• Molecular Weight: 931.095

Synonyms:Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester

Chemical Property of Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester

There total 7 articles about Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

heptane-1,4,7-triol (3920-53-4) → Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (183273-93-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 78 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

2: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

4: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

5: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

6: pyridine / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00731-4

Reference yield:

4-oxo-heptanedioic acid dimethyl ester (22634-92-0) → Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (183273-93-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 36 percent / LiAlH₄ / diethyl ether / 0.5 h / Heating

2: 78 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

3: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

5: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

6: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

7: pyridine / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00731-4

Reference yield:

7-[(4-Methoxy-phenyl)-diphenyl-methoxy]-heptane-1,4-diol (183273-86-1) → Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (183273-93-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

2: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

3: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

4: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

5: pyridine / 1 h / 20 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00731-4

upstream raw materials:

phenoxyacetic anhydride

4,7-Bis-(3-amino-propylamino)-heptan-1-ol

heptane-1,4,7-triol

4-oxo-heptanedioic acid dimethyl ester

Downstream raw materials:

Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

C₆₇H₉₅N₆O₁₈PSi₂

N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide

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