N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide

Base Information

• Chemical Name: N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide
• CAS No.: 183273-95-2
• Molecular Formula: C₄₅H₅₆N₄O₉
• Molecular Weight: 796.961
• Mol file: 183273-95-2.mol

Synonyms:N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide

Chemical Property of N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide

There total 9 articles about N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (183273-93-0) → N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide (183273-95-2)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 3h;

DOI:10.1016/0040-4020(96)00731-4

Reference yield:

heptane-1,4,7-triol (3920-53-4) → N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide (183273-95-2)

Guidance literature:

Multi-step reaction with 7 steps

1: 78 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

2: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

3: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

4: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

5: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

6: pyridine / 1 h / 20 °C

7: 99 percent / NH₃ / methanol / 3 h / 20 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; ammonia; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00731-4

Reference yield:

4-oxo-heptanedioic acid dimethyl ester (22634-92-0) → N-(1-(3-Hydroxy-propyl)-4-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-butyl)-2-phenoxy-N-[3-(2-phenoxy-acetylamino)-propyl]-acetamide (183273-95-2)

Guidance literature:

Multi-step reaction with 8 steps

1: 36 percent / LiAlH₄ / diethyl ether / 0.5 h / Heating

2: 78 percent / pyridine / CH₂Cl₂ / 18 h / 20 °C

3: 59 percent / pyridine / CH₂Cl₂ / 1 h / 0 - 20 °C

4: 91 percent / NaN₃ / dimethylformamide / 18 h / 20 °C

5: 1.) H₂ / 1.) 10percent Pd/C / 1.) MeOH, 20 deg C, 1 h, 2.) DMF, 20 deg C, 14 h

6: LiAlH₄, AlCl₃ / tetrahydrofuran; diethyl ether / 15 h / 20 °C

7: pyridine / 1 h / 20 °C

8: 99 percent / NH₃ / methanol / 3 h / 20 °C

With pyridine; lithium aluminium tetrahydride; aluminium trichloride; sodium azide; ammonia; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/0040-4020(96)00731-4

upstream raw materials:

Phenoxy-acetic acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester

heptane-1,4,7-triol

4-oxo-heptanedioic acid dimethyl ester

phenoxyacetic anhydride

Downstream raw materials:

Phosphoric acid 4,7-bis-{(2-phenoxy-acetyl)-[3-(2-phenoxy-acetylamino)-propyl]-amino}-heptyl ester (2R,3S,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester methyl ester

C₆₇H₉₅N₆O₁₈PSi₂