N-(5-chloro-2-methylphenyl)benzamide

Base Information

• Chemical Name: N-(5-chloro-2-methylphenyl)benzamide
• CAS No.: 10282-51-6
• Molecular Formula: C14H12 Cl N O
• Molecular Weight: 245.7042
• NSC Number: 164396
• DSSTox Substance ID: DTXSID90304160
• Wikidata: Q82049892
• Mol file: 10282-51-6.mol

Synonyms:N-(5-chloro-2-methylphenyl)benzamide;10282-51-6;NSC164396;Cambridge id 7169787;SCHEMBL7596928;DTXSID90304160;STK208800;AKOS002975169;NSC-164396;AN-652/40847950

Chemical Property of N-(5-chloro-2-methylphenyl)benzamide

Chemical Property:

• Vapor Pressure: 0.00215mmHg at 25°C
• Boiling Point: 289.8°Cat760mmHg
• Flash Point: 129.1°C
• Density: 1.25g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 245.0607417
• Heavy Atom Count: 17
• Complexity: 263

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)Cl)NC(=O)C2=CC=CC=C2

Technology Process of N-(5-chloro-2-methylphenyl)benzamide

There total 3 articles about N-(5-chloro-2-methylphenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

benzoyl chloride (98-88-4) + 5-chloro-2-methyl-benzenamine (95-79-4) → N-(5-chloro-2-methylphenyl)-benzamide (10282-51-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 ℃; for 2h; Reflux;

DOI:10.1021/acs.jmedchem.5b00310

Reference yield:

2,4-dichlorotoluene (95-73-8) + benzamide (55-21-0,27208-38-4) → N-(5-chloro-2-methylphenyl)-benzamide (10282-51-6) + N-(3-chloro-4-methylphenyl)benzamide (10286-78-9)

Guidance literature:

With potassium phosphate; C₄₈H₆₆NO₃PPd; In 1,4-dioxane; at 120 ℃; for 0.5h; Overall yield = 30 percentChromat.;

DOI:10.1021/acs.orglett.9b02259

Reference yield:

→ N-(5-chloro-2-methylphenyl)-benzamide (10282-51-6)

Guidance literature:

entspr. Anilin, Benzoesaeureanhydrid;

upstream raw materials:

benzoyl chloride

5-chloro-2-methyl-benzenamine

2,4-dichlorotoluene

benzamide

Downstream raw materials:

6-chloro-2-phenylindole

Refernces

• 1、 La Regina, Giuseppe,Bai, Ruoli,Coluccia, Antonio,Famiglini, Valeria,Pelliccia, Sveva,Passacantilli, Sara,Mazzoccoli, Carmela,Ruggieri, Vitalba,Verrico, Annalisa,Miele, Andrea,Monti, Ludovica,Nalli, Marianna,Alfonsi, Romina,Di Marcotullio, Lucia,Gulino, Alberto,Ricci, Biancamaria,Soriani, Alessandra,Santoni, Angela,Caraglia, Michele,Porto, Stefania,Da Pozzo, Eleonora,Martini, Claudia,Brancale, Andrea,Marinelli, Luciana,Novellino, Ettore,Vultaggio, Stefania,Varasi, Mario,Mercurio, Ciro,Bigogno, Chiara,Dondio, Giulio,Hamel, Ernest,Lavia, Patrizia,Silvestri, Romano. "New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer". . p. 5789 - 5807. Retrieved 2015/08/24.