Technology Process of 2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carboxylic acid
There total 6 articles about 2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile;
With
water; sodium hydroxide;
In
ethanol;
at 90 ℃;
for 15h;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice
2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice
3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 6 h / Inert atmosphere; Reflux
4.1: acetic acid / 60 °C
4.2: 0.08 h / 60 °C
5.1: phosphorus trichloride / chloroform / 1 h / 60 °C
6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C
With
sulfuric acid; water; nitric acid; sodium carbonate; acetic acid; sodium hydroxide; phosphorus trichloride;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; chloroform; water; toluene;
3.1: Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice
2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene; water / 6 h / Inert atmosphere; Reflux
3.1: acetic acid / 60 °C
3.2: 0.08 h / 60 °C
4.1: phosphorus trichloride / chloroform / 1 h / 60 °C
5.1: sodium hydroxide; water / ethanol / 15 h / 90 °C
With
sulfuric acid; water; nitric acid; sodium carbonate; acetic acid; sodium hydroxide; phosphorus trichloride;
tetrakis(triphenylphosphine) palladium(0);
In
ethanol; chloroform; water; toluene;
2.1: Suzuki Coupling;
