2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

Base Information

Chemical Name:2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide
CAS No.:1373844-51-9
Molecular Formula:C₁₇H₁₁BrN₄O₃
Molecular Weight:399.203
Hs Code.:

Synonyms:2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

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Chemical Property of 2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

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Technology Process of 2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

There total 4 articles about 2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 773837-37-9
sodium cyanide

: 1373844-49-5
5-cyclopropyl-2,4-dinitrobenzaldehyde

: 106-40-1
4-bromo-aniline

: 1373844-51-9
2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

Guidance literature:: 5-cyclopropyl-2,4-dinitrobenzaldehyde; 4-bromo-aniline; With acetic acid; at 60 ℃;

sodium cyanide; In acetic acid; at 60 ℃; for 0.0833333h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373844-51-9
2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice

2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

4.1: acetic acid / 60 °C

4.2: 0.08 h / 60 °C

With sulfuric acid; nitric acid; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; 3.1: Suzuki Coupling;

Reference yield:

: 20357-20-4
5-bromo-2-nitrobenzaldehyde

: 1373844-51-9
2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carbonitrile 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

3.1: acetic acid / 60 °C

3.2: 0.08 h / 60 °C

With sulfuric acid; nitric acid; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; 2.1: Suzuki Coupling;