2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

Base Information

Chemical Name:2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide
CAS No.:1373844-57-5
Molecular Formula:C₁₈H₁₅BrN₄O₃
Molecular Weight:415.246
Hs Code.:

Synonyms:2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

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Chemical Property of 2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

Chemical Property:

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Technology Process of 2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

There total 7 articles about 2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1373844-55-3
2-(4-bromophenyl)-5-cyclopropyl-6-nitro-2H-indazole-3-carboxylic acid

: 74-89-5
methylamine

: 1373844-57-5
2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

Guidance literature:: With pyridine; trichlorophosphate; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 3132-99-8
m-bromobenzoic aldehyde

: 1373844-57-5
2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid / 0.42 h / cooling with ice

2.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

4.1: acetic acid / 60 °C

4.2: 0.08 h / 60 °C

5.1: phosphorus trichloride / chloroform / 1 h / 60 °C

6.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

7.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

With pyridine; sulfuric acid; water; nitric acid; sodium carbonate; acetic acid; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; chloroform; water; toluene; 3.1: Suzuki Coupling;

Reference yield:

: 20357-20-4
5-bromo-2-nitrobenzaldehyde

: 1373844-57-5
2-(4-bromophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid; sulfuric acid / 6 h / 50 °C / cooling with ice

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 6 h / Inert atmosphere; Reflux

3.1: acetic acid / 60 °C

3.2: 0.08 h / 60 °C

4.1: phosphorus trichloride / chloroform / 1 h / 60 °C

5.1: sodium hydroxide; water / ethanol / 15 h / 90 °C

6.1: pyridine; trichlorophosphate / tetrahydrofuran / 1 h / 0 °C

With pyridine; sulfuric acid; water; nitric acid; sodium carbonate; acetic acid; sodium hydroxide; trichlorophosphate; phosphorus trichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; chloroform; water; toluene; 2.1: Suzuki Coupling;