2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

Base Information

Chemical Name:2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester
CAS No.:690631-47-1
Molecular Formula:C₂₁H₃₁O₈P
Molecular Weight:442.446
Hs Code.:

Synonyms:2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

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Chemical Property of 2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

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Technology Process of 2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

There total 6 articles about 2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42726-73-8
methyl t-butyl malonate

: 690631-42-6
(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

: 690631-47-1
2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

: 2-[(E)-(S)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

Guidance literature:: methyl t-butyl malonate; With sodium hydride; In tetrahydrofuran; at 20 ℃;

(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 70 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1021/jo035795h

Reference yield:

: 24743-14-4
1-allyl-3-methoxybenzene

: 690631-47-1
2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Grubbs catalyst / CH₂Cl₂ / 12 h / 40 °C

2.1: 95 percent / pyridine; DMAP / CH₂Cl₂ / 24 h / 20 °C

3.1: NaH / tetrahydrofuran / 20 °C

3.2: Pd(PPh₃)4 / tetrahydrofuran / 1 h / 70 °C

With pyridine; dmap; Grubbs catalyst first generation; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo035795h

Reference yield:

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 690631-47-1
2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 97 percent / tetrahydrofuran / 24 h / 20 °C

2.1: Grubbs catalyst / CH₂Cl₂ / 12 h / 40 °C

3.1: 95 percent / pyridine; DMAP / CH₂Cl₂ / 24 h / 20 °C

4.1: NaH / tetrahydrofuran / 20 °C

4.2: Pd(PPh₃)4 / tetrahydrofuran / 1 h / 70 °C

With pyridine; dmap; Grubbs catalyst first generation; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo035795h