(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

Base Information

Chemical Name:(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate
CAS No.:690631-42-6
Molecular Formula:C₁₅H₂₁O₇P
Molecular Weight:344.301
Hs Code.:

Synonyms:(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

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Chemical Property of (1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

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Technology Process of (1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

There total 5 articles about (1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 79-22-1
methyl chloroformate

: 690631-43-7
[(E)-(R)-1-Hydroxy-4-(3-methoxy-phenyl)-but-2-enyl]-phosphonic acid dimethyl ester

: 690631-42-6
(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jo035795h

Reference yield: 68.0%

: 24743-14-4
1-allyl-3-methoxybenzene

: 1039731-28-6
dimethyl [1-(methoxycarbonyloxy)-5-methyl-2-hexenyl]phosphonate

: 690631-42-6
(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

Guidance literature:: With Grubbs catalyst first generation; In dichloromethane; at 40 ℃; for 12h;
DOI:10.1021/jo035795h

Reference yield:

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 690631-42-6
(1R)(2E) dimethyl [1-(methoxycarbonyloxy)-4-(3-methoxyphenyl)-2-butenyl] phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / tetrahydrofuran / 24 h / 20 °C

2: Grubbs catalyst / CH₂Cl₂ / 12 h / 40 °C

3: 95 percent / pyridine; DMAP / CH₂Cl₂ / 24 h / 20 °C

With pyridine; dmap; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo035795h