3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

Base Information

Chemical Name:3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone
CAS No.:690631-39-1
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

Suppliers and Price of 3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

There total 6 articles about 3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 690631-47-1
2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester

: 690631-39-1
3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

Guidance literature:: 2-[(E)-(R)-3-(Dimethoxy-phosphoryl)-1-(3-methoxy-benzyl)-allyl]-malonic acid tert-butyl ester methyl ester; With ozone; In methanol; dichloromethane; at -78 ℃;

With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃;
DOI:10.1021/jo035795h

Reference yield:

: 24743-14-4
1-allyl-3-methoxybenzene

: 690631-39-1
3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: Grubbs catalyst / CH₂Cl₂ / 12 h / 40 °C

2.1: 95 percent / pyridine; DMAP / CH₂Cl₂ / 24 h / 20 °C

3.1: NaH / tetrahydrofuran / 20 °C

3.2: Pd(PPh₃)4 / tetrahydrofuran / 1 h / 70 °C

4.1: O₃ / methanol; CH₂Cl₂ / -78 °C

4.2: 57 percent / NaBH₄ / methanol; CH₂Cl₂ / 20 °C

With pyridine; dmap; Grubbs catalyst first generation; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo035795h

Reference yield:

: 36282-40-3
(3-methoxyphenyl)magnesium bromide

: 690631-39-1
3-(tert-butoxycarbonyl)-4-[(3-methoxyphenyl)methyl]-dihydro-2(3H)-furanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / tetrahydrofuran / 24 h / 20 °C

2.1: Grubbs catalyst / CH₂Cl₂ / 12 h / 40 °C

3.1: 95 percent / pyridine; DMAP / CH₂Cl₂ / 24 h / 20 °C

4.1: NaH / tetrahydrofuran / 20 °C

4.2: Pd(PPh₃)4 / tetrahydrofuran / 1 h / 70 °C

5.1: O₃ / methanol; CH₂Cl₂ / -78 °C

5.2: 57 percent / NaBH₄ / methanol; CH₂Cl₂ / 20 °C

With pyridine; dmap; Grubbs catalyst first generation; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo035795h