N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Base Information

Chemical Name:N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide
CAS No.:1268273-69-3
Molecular Formula:C₃₁H₃₄N₄O₅S
Molecular Weight:574.701
Hs Code.:

Synonyms:N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

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Chemical Property of N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

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Technology Process of N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

There total 5 articles about N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1268273-68-2
5-(3-aminophenylthio)-4,6-dimethoxy-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine

: 79-03-8
propionyl chloride

: 1268273-69-3
N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1268273-69-3
N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline / dimethyl sulfoxide / 20 h / 125 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; potassium carbonate; triethylamine; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 36315-01-2,256642-28-1
4,6-dimethoxy-2-aminopyrimidine

: 1268273-69-3
N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 20 °C

2.1: N-iodo-succinimide / acetonitrile / 1 h / 20 °C / Inert atmosphere

3.1: potassium carbonate / copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline / dimethyl sulfoxide / 20 h / 125 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

With N-iodo-succinimide; sodium hydride; potassium carbonate; triethylamine; copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;