ATROPINE SULFATE

Base Information

• Chemical Name: ATROPINE SULFATE
• CAS No.: 73791-47-6
• Molecular Formula: C₁₇H₂₃NO₃*H₂O*H₂O₄S
• Molecular Weight: 405.469
• Mol file: 73791-47-6.mol

Synonyms:ATROPINE SULFATE, ATROPA BELLADONNA (LINNAEUS);ATROPINE SULPHATE

Chemical Property of ATROPINE SULFATE

Chemical Property:

• Vapor Pressure: 3.76E-08mmHg at 25°C
• Melting Point: 189-192 °C (A)(lit.)
• Boiling Point: 429.8 °C at 760 mmHg
• Flash Point: 213.7 °C
• PSA: 132.75000
• LogP: 2.29680

Purity/Quality:

99%, ^*data from raw suppliers

Endo-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate sulfate dihydrate(2:1:2) 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 26/28
• Safety Statements: 23-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ATROPINE SULFATE

There total 3 articles about ATROPINE SULFATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Atropine (51-55-8) → atropine sulphate monohydrate (5908-99-6,5979-02-2,6835-16-1,73791-47-6)

Guidance literature:

Atropine; In ethanol; at 75 ℃; Reflux; Large scale;

With sulfuric acid; In ethanol; at 25 ℃; for 0.5h; Large scale;

Reference yield:

methyl 2-formyl-2-phenylacetate (5894-79-1) → atropine sulphate monohydrate (5908-99-6,5979-02-2,6835-16-1,73791-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 3 h / 110 °C / Large scale

2.1: palladium on activated charcoal; acetic acid / methanol; chloroform / 8 h / 12 - 15 °C / Large scale

3.1: ethanol / 75 °C / Reflux; Large scale

3.2: 0.5 h / 25 °C / Large scale

With palladium on activated charcoal; acetic acid; In methanol; ethanol; chloroform; toluene;

Reference yield:

3-tropanol (120-29-6) → atropine sulphate monohydrate (5908-99-6,5979-02-2,6835-16-1,73791-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene / 3 h / 110 °C / Large scale

2.1: palladium on activated charcoal; acetic acid / methanol; chloroform / 8 h / 12 - 15 °C / Large scale

3.1: ethanol / 75 °C / Reflux; Large scale

3.2: 0.5 h / 25 °C / Large scale

With palladium on activated charcoal; acetic acid; In methanol; ethanol; chloroform; toluene;

upstream raw materials:

methyl 2-formyl-2-phenylacetate

Atropine

3-tropanol

Downstream raw materials:

Tropic acid

apoatropine

Refernces