methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

Base Information

Chemical Name:methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate
CAS No.:1001399-54-7
Molecular Formula:C₁₃H₁₄FNO₅S
Molecular Weight:315.322
Hs Code.:

Synonyms:methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

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Chemical Property of methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

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Technology Process of methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

There total 5 articles about methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 5617-70-9
cycl-isopropylidene cyclopropane-1,1-dicarboxylate

: 832755-13-2
2-fluoro-4-methanesulfonylaniline

: 1001399-54-7
methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: cycl-isopropylidene cyclopropane-1,1-dicarboxylate; 2-fluoro-4-methanesulfonylaniline; In acetonitrile; at 60 - 70 ℃; for 8h;

With sulfuric acid; In methanol; for 2h; Heating / reflux;

Reference yield:

: 16019-30-0
6-hydroxy-5-(2-propen-1-yl)-4(1H)-pyrimidinone

: 1001399-54-7
methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 4 h / Inert atmosphere; Reflux

2.1: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: acetonitrile / 3 h / 60 °C / Inert atmosphere

3.2: 5 h / 70 °C

4.1: sulfuric acid / methanol / 2 h / Reflux

With sulfuric acid; sodium hydride; trichlorophosphate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm301404a

Reference yield:

: 16019-31-1
5-allyl-4,6-dichloropyrimidine

: 1001399-54-7
methyl 1-[2-fluoro-4-(methylsulfonyl)phenyl]-2-oxo-3-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.1: acetonitrile / 3 h / 60 °C / Inert atmosphere

2.2: 5 h / 70 °C

3.1: sulfuric acid / methanol / 2 h / Reflux

With sulfuric acid; sodium hydride; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/jm301404a