1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

Base Information

Chemical Name:1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS No.:1426688-70-1
Molecular Formula:C₂₃H₂₃FN₄O
Molecular Weight:390.46
Hs Code.:

Synonyms:1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

Suppliers and Price of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

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Chemical Property of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

There total 5 articles about 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426688-71-2
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)spiro[indoline-3,3'-pyrrolidin]-2-one

: 74-88-4
methyl iodide

: 1426688-70-1
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Sealed tube;

Reference yield:

: 205383-87-5
tert-butyl 2-oxospiro[indoline-3,3’-pyrrolidine]-1'-carboxylate

: 1426688-70-1
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 20 °C

2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation; Sealed tube

3: trifluoroacetic acid / 2 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1426689-05-5
tert-butyl 1-(4-bromo-2-fluorobenzyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate

: 1426688-70-1
1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran; water / 0.17 h / 160 °C / Microwave irradiation; Sealed tube

2: trifluoroacetic acid / 2 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Sealed tube

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;