1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone

Base Information

• Chemical Name: 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone
• CAS No.: 52217-37-5
• Molecular Formula: C₁₆H₁₅N₃O
• Molecular Weight: 265.315
• Mol file: 52217-37-5.mol

Synonyms:1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone

Chemical Property of 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone

There total 5 articles about 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + acetylacetone (123-54-6,81235-32-7) → 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone (52217-37-5)

Guidance literature:

With indium(III) chloride; In water; at 209.84 ℃; for 0.283333h; Microwave irradiation;

DOI:10.1039/c7ra10127a

Reference yield:

phenylhydrazine (100-63-0) → 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone (52217-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Heating

2: indium(III) chloride / water / 0.28 h / 209.84 °C / Microwave irradiation

With indium(III) chloride; In water;

DOI:10.1039/c7ra10127a

Reference yield:

(E)-N2-(4-formyl-3-methyl-1-phenyl-1H-pyrazol-5-yl)-N1,N1-dimethylformamidine → 1-(3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridin-5-il)etanone (52217-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl

With hydrogenchloride;

DOI:10.1002/jccs.200700072

upstream raw materials:

acetylacetone

5-amino-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde

formaldehyd

1-Phenyl-3-methyl-5-aminopyrazole