dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Base Information

Chemical Name:dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate
CAS No.:1426937-89-4
Molecular Formula:C₂₂H₁₈FNO₄S
Molecular Weight:411.454
Hs Code.:

Synonyms:dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

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Chemical Property of dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

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Technology Process of dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

There total 3 articles about dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1426937-88-3
(2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid

: 762-42-5
dimethyl acetylenedicarboxylate

: 1426937-89-4
dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Guidance literature:: In acetic anhydride; at 110 ℃; for 4h;
DOI:10.1016/j.ejmech.2012.11.036

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1426937-89-4
dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / -10 - 20 °C

1.2: 1 h / -10 - 20 °C

2.1: acetic anhydride / 4 h / 110 °C

With triethylamine; In tetrahydrofuran; acetic anhydride;
DOI:10.1016/j.ejmech.2012.11.036

Reference yield:

: 196930-46-8
(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid

: 1426937-89-4
dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / -10 - 20 °C

1.2: 1 h / -10 - 20 °C

2.1: acetic anhydride / 4 h / 110 °C

With triethylamine; In tetrahydrofuran; acetic anhydride;
DOI:10.1016/j.ejmech.2012.11.036