(2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid

Base Information

• Chemical Name: (2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid
• CAS No.: 1426937-88-3
• Molecular Formula: C₁₇H₁₄FNO₃S
• Molecular Weight: 331.367
• Mol file: 1426937-88-3.mol

Synonyms:(2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid

Chemical Property of (2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid

There total 1 articles about (2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid (196930-46-8) + 4-fluorobenzoyl chloride (403-43-0) → (2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid (1426937-88-3)

Guidance literature:

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid; With triethylamine; In tetrahydrofuran; at -10 - 20 ℃; for 0.25h;

4-fluorobenzoyl chloride; In tetrahydrofuran; at -10 - 20 ℃; for 1h;

DOI:10.1016/j.ejmech.2012.11.036

Reference yield: 97.0%

(2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid (1426937-88-3) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate (1426937-89-4)

Guidance literature:

In acetic anhydride; at 110 ℃; for 4h;

DOI:10.1016/j.ejmech.2012.11.036

Reference yield:

(2R,4R)-3-(4-fluorobenzoyl)-2-phenylthiazolidine-4-carboxylic acid (1426937-88-3) → C20H18FNO2S (1426937-91-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / 4 h / 110 °C

2: lithium aluminium tetrahydride / diethyl ether; dichloromethane / 1.5 h / 0 °C / Reflux

With lithium aluminium tetrahydride; In diethyl ether; dichloromethane; acetic anhydride;

DOI:10.1016/j.ejmech.2012.11.036

upstream raw materials:

(4R)-2-phenyl-1,3-thiazolidine-4-carboxylic acid

4-fluorobenzoyl chloride

Downstream raw materials:

C₂₀H₁₈FNO₂S

dimethyl (3R)-5-(4-fluorophenyl)-3-phenyl-1H,3H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylate