2-(methylamino)propiophenone

Base Information

• Chemical Name: 2-(methylamino)propiophenone
• CAS No.: 5650-44-2
• Deprecated CAS: 28521-94-0
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• European Community (EC) Number: 227-092-7
• UNII: 386QA522QG
• DSSTox Substance ID: DTXSID30863589
• Nikkaji Number: J31.084K
• Wikipedia: Methcathinone
• Wikidata: Q420643
• Pharos Ligand ID: 1HP7Q84DJR22
• Metabolomics Workbench ID: 49633
• ChEMBL ID: CHEMBL4070364
• Mol file: 5650-44-2.mol

Synonyms:Propiophenone,2-(methylamino)- (6CI,7CI,8CI);1-Phenyl-1-oxo-2-methylaminopropane;1-Phenyl-2-methylamino-1-propanone;Ephedrone;Methcathinone;Monomethylpropion;UR 1431;

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Chemical Property of 2-(methylamino)propiophenone

Chemical Property:

• Vapor Pressure: 0.00349mmHg at 25°C
• Melting Point: 182-184 °C
• Refractive Index: 1.557
• Boiling Point: 281.8 °C at 760 mmHg
• PKA: 7.14±0.10(Predicted)
• Flash Point: 118.2 °C
• Density: 1.04 g/cm³
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(=O)C1=CC=CC=C1)NC

Technology Process of 2-(methylamino)propiophenone

There total 26 articles about 2-(methylamino)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C16H21NO6 → (-)-Methcathinone (5650-44-2,28521-94-0,112117-24-5)

Guidance literature:

With pyridinium p-toluenesulfonate; In water; acetone; for 3h; Heating;

Reference yield: 90.0%

2-methylamino-1-phenylpropanol (299-42-3,7009-81-6,90-83-5,6912-63-6) → methcathinone (5650-44-2,28521-94-0,112117-24-5)

Guidance literature:

With trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; for 2.5h; Ambient temperature;

DOI:10.1021/jo00127a036

Reference yield: 72.0%

ephedrine (299-42-3,7009-81-6,90-83-5,6912-63-6) → (-)-Methcathinone (5650-44-2,28521-94-0,112117-24-5)

Guidance literature:

With tert.-butylhydroperoxide; C₂₀H₂₂CoN₁₂O₆S₃; In water; at 100 ℃; for 0.166667h; Reagent/catalyst; Catalytic behavior; Microwave irradiation;

DOI:10.1016/j.molcata.2016.10.023

upstream raw materials:

rac-pseudoephedrine

2-(N-benzyl-N-methylamino)-1-phenylpropan-1-one

2-bromo-1-phenyl-1-propanone

methylamine

Downstream raw materials:

(+)(2Ξ,3S)-3-methylamino-2-phenyl-butan-2-ol

2-heptyl-1,5-dimethyl-4-phenyl-2,5-dihydro-1H-imidazole

Methamphetamin

ephedrine

Refernces

• 1、 -. "Preparation of (S)-(-)-alpha-methylamino propiophenone". Paragraph 0011-0012. . Retrieved 2021/06/26.
• 2、 -. "Preparation methods for ephedrine or pseudoephedrine and for ephedrine or pseudoephedrine intermediate". Paragraph 0114; 0115. . Retrieved 2017/04/14.