5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

Base Information

Chemical Name:5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates
CAS No.:84719-00-6
Molecular Formula:C₆₆H₆₄N₅O₁₃P
Molecular Weight:1166.23
Hs Code.:

Synonyms:5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

Chemical Property:

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Technology Process of 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

There total 4 articles about 5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13084-61-2
3'-O-(4-methoxytriphenylmethyl)thymidine

: 84719-00-6
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 1.)collidine 2.)I₂, H₂O / tetrahydrofuran

2: 91 percent

3: 1.)Dowex(Py⁺) 2.)Ph₃P-CCl₄

With 2,3,5-trimethyl-pyridine; triphenylphosphine-carbon tetrachloride; Dowex(Py⁺); water; iodine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)88727-4

Reference yield:

: 42926-80-7
5'-O-(4-monomethoxytrityl)-2'-deoxythymidine

: 84719-00-6
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 1.)collidine 2.)I₂, H₂O / tetrahydrofuran

2: 91 percent

3: 1.)Dowex(Py⁺) 2.)Ph₃P-CCl₄

With 2,3,5-trimethyl-pyridine; triphenylphosphine-carbon tetrachloride; Dowex(Py⁺); water; iodine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)88727-4

Reference yield:

: 90662-75-2
pyridinium 5'-O-monomethoxytritylthymidine 3'-phosphoranilidate

: 13084-61-2
3'-O-(4-methoxytriphenylmethyl)thymidine

: 84774-19-6
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

: 84719-00-6
5'-monomethoxytritylthymidyl(3'-5')-3'-monomethoxytritylthymidyl phosphoranilidates

: P¹,P²-di-(phenylamino)-P¹,P²-di-<3'-(5'-monomethoxytritylthymidyl-1-yl)>-pyrophosphordiamidate

Guidance literature:: With Triphenylsilyl chloride; In pyridine; for 40h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/0040-4020(84)85099-1