N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide

Base Information

• Chemical Name: N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide
• CAS No.: 333320-72-2
• Molecular Formula: C₁₄H₁₄INO₄S
• Molecular Weight: 419.24
• Mol file: 333320-72-2.mol

Synonyms:3,4-dimethoxy-N-(4-iodophenyl)benzenesulfonamide

Chemical Property of N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide

Chemical Property:

Purity/Quality:

N-(4-IODOPHENYL)-3,4-DIMETHOXYBENZENESULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide

There total 1 articles about N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dimethoxybenzene-1-sulfonyl chloride (23095-31-0) + p-aminoiodobenzene (540-37-4) → 3,4-dimethoxy-N-(4-iodophenyl)benzenesulfonamide (333320-72-2)

Guidance literature:

3,4-dimethoxybenzene-1-sulfonyl chloride; p-aminoiodobenzene; With triethylamine; In dichloromethane;

With sodium methylate; In methanol;

DOI:10.1016/S0960-894X(01)00552-2

Reference yield:

acrylic acid (79-10-7) + 3,4-dimethoxy-N-(4-iodophenyl)benzenesulfonamide (333320-72-2) → 3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phenyl]-acrylic acid (501682-95-7)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; triethylamine; tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1016/S0960-894X(01)00552-2

Reference yield:

3,4-dimethoxy-N-(4-iodophenyl)benzenesulfonamide (333320-72-2) → 3-[4-(3,4-dimethoxy-benzenesulfonylamino)-phenyl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: Et₃N / Pd-EnCat^TM / dimethylformamide / 18 h / 90 °C

2.1: diethylaminopropylcarbodiimide hydrochloride; 1-hydroxybenzotriazole / dimethylformamide / 0.33 h / 20 °C

2.2: dimethylformamide / 24 h / 50 °C

With 1-ethyl-3-(3-ethylaminopropyl)carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine; Pd-EnCat^TM; In N,N-dimethyl-formamide; 1.1: Heck olefination;

DOI:10.1039/b313414h

upstream raw materials:

3,4-dimethoxybenzene-1-sulfonyl chloride

p-aminoiodobenzene

Downstream raw materials:

3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phenyl]-acrylic acid

PX117794