5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

Base Information

Chemical Name:5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene
CAS No.:333447-56-6
Molecular Formula:C₂₆H₂₀Cl₃FO₅
Molecular Weight:537.799
Hs Code.:

Synonyms:5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

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Chemical Property of 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

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Technology Process of 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

There total 3 articles about 5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 200190-87-0
3-bromo-6-chloro-4-fluoro-toluene

: 333447-57-7
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-2-chloro-4-fluorotoluene

: 333447-56-6
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

Guidance literature:: 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride; With iodine; magnesium; In tetrahydrofuran; at 40 ℃; for 1h;

With cadmium(II) chloride; for 1h; Heating;

3-bromo-6-chloro-4-fluoro-toluene; at 25 ℃; for 12h;
DOI:10.1081/NCN-100001435

Reference yield:

: 452-73-3
2-chloro-4-fluorotoluene

: 333447-56-6
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 70 percent / Br₂; Fe / 5 h / 60 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 30 percent / 12 h / 25 °C

With bromine; iodine; iron; magnesium; In tetrahydrofuran;
DOI:10.1081/NCN-100001435

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 333447-56-6
5-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-2-chloro-4-fluorotoluene

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcCl; MeOH / 0.75 h / 25 °C

1.2: pyridine; DMAP / 0 - 25 °C

1.3: 82 percent / HCl gas / diethyl ether; acetic acid / 0.17 h / 0 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 30 percent / 12 h / 25 °C

With methanol; iodine; magnesium; acetyl chloride; In tetrahydrofuran;
DOI:10.1081/NCN-100001435