methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate

Base Information

• Chemical Name: methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate
• CAS No.: 379679-64-8
• Molecular Formula: C₁₃H₁₁FO₃
• Molecular Weight: 234.227
• Mol file: 379679-64-8.mol

Synonyms:methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate

Chemical Property of methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate

There total 13 articles about methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 3-bromo-2-(4-fluorophenyl)-2-cyclopenten-1-one (379679-62-6) → methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate (379679-64-8)

Guidance literature:

With tributyl-amine; 5percent Pd/C; In N,N-dimethyl acetamide; at 60 ℃; for 12h; under 517.162 Torr;

DOI:10.1021/jo025883m

Reference yield: 90.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 3-bromo-2-(4-fluorophenyl)-2-cyclopenten-1-one (379679-62-6) → 2-(4-fluoro-phenyl)-3-oxo-cyclopent-1-enecarboxylic acid + methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate (379679-64-8) + 3-methoxy-2-(4-fluorophenyl)-2-cyclopenten-1-one (379679-67-1)

Guidance literature:

With tributyl-amine; ISOPROPYLAMIDE; palladium on activated charcoal; at 60 ℃; for 8h; under 4137.18 Torr; Title compound not separated from byproducts;

DOI:10.1021/ja016877v

Reference yield: 90.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 3-bromo-2-(4-fluorophenyl)-2-cyclopenten-1-one (379679-62-6) → methyl 2-(4-fluorophenyl)-3-oxo-1-cyclopent-1-enecarboxylate (379679-64-8) + 3-methoxy-2-(4-fluorophenyl)-2-cyclopenten-1-one (379679-67-1)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; tributyl-amine; at 60 ℃; for 16h; under 2068.59 Torr;

DOI:10.1021/jo025883m

upstream raw materials:

methanol

carbon monoxide

3-bromo-2-(4-fluorophenyl)-2-cyclopenten-1-one

(+/-)-methyl 2-(4-fluorophenyl)-3-hydroxycyclopent-1-enecarboxylate

Downstream raw materials:

(+/-)-methyl 2-(4-fluorophenyl)-3-hydroxycyclopent-1-enecarboxylate

C₁₃H₁₃FO₃

C₁₃H₁₃FO₃

[(1R,2R,3S)-3-{(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy}-2-(4-fluorophenyl)cyclopentyl]methanol