3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

Base Information

Chemical Name:3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal
CAS No.:947594-86-7
Molecular Formula:C₂₇H₃₃ClN₂O₅
Molecular Weight:501.022
Hs Code.:

Synonyms:3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

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Chemical Property of 3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

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Technology Process of 3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

There total 4 articles about 3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 109224-71-7
2-(aminomethyl)-2-(3,4-dimethoxyphenyl)-1,2-dioxolane

: 140633-58-5
3β-(4-Chlorophenyl)-tropane-2β-carboxylic acid

: 947594-86-7
3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 25 ℃;
DOI:10.1021/jm0703035

Reference yield:

: 187101-52-6
2-azido-1-(3,4-dimethoxyphenyl)ethanone

: 947594-86-7
3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 80 percent / boron trifluoride etherate / CH₂Cl₂ / 20 °C

2.1: triphenylphosphine / tetrahydrofuran

2.2: 85 percent / water / tetrahydrofuran

3.1: 55 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

With 1-hydroxy-7-aza-benzotriazole; boron trifluoride diethyl etherate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2.1: Staudinger reaction;
DOI:10.1021/jm0703035

Reference yield:

: 947594-79-8
3,4-dimethoxyphenacyl azide ethylene ketal

: 947594-86-7
3β-(4-chlorophenyl)tropane-2β-N-(3,4-dimethoxyphenacyl)carboxamide ethylene ketal

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / tetrahydrofuran

1.2: 85 percent / water / tetrahydrofuran

2.1: 55 percent / 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide / dimethylformamide / 25 °C

With 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Staudinger reaction;
DOI:10.1021/jm0703035