methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Base Information

Chemical Name:methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate
CAS No.:1178976-79-8
Molecular Formula:C₂₃H₂₄ClFN₄O₄
Molecular Weight:474.919
Hs Code.:

Synonyms:methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

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Chemical Property of methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

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Technology Process of methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

There total 5 articles about methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1178976-89-0
cis/trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylic acid

: 1178976-88-9
Methyl cis-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

: 1178976-79-8
methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Guidance literature:: With thionyl chloride; Cooling with ice; Reflux;

Reference yield:

: 2106-04-9
3-chloro-2-fluoroaniline

: 1178976-88-9
Methyl cis-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

: 1178976-79-8
methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; trichlorophosphate / acetonitrile / 2 h / 40 °C / Inert atmosphere; Reflux

1.2: 20 - 40 °C / Inert atmosphere

1.3: 20 °C

2.1: ethanol; water / 4 h / Reflux

3.1: sodium hydroxide; water / 25 h / 135 °C

3.2: 20 °C

4.1: thionyl chloride / Cooling with ice; Reflux

With thionyl chloride; water; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; water; acetonitrile;

Reference yield:

: 1046137-42-1
4-[(3-chloro-2-fluoro-phenyl)amino]-6-(4-oxo-cyclohexyloxy)-7-methoxy-quinazoline

: 1178976-88-9
Methyl cis-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

: 1178976-79-8
methyl trans-1-amino-4-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy-quinazolin-6-yloxy]-cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 4 h / Reflux

2.1: sodium hydroxide; water / 25 h / 135 °C

2.2: 20 °C

3.1: thionyl chloride / Cooling with ice; Reflux

With thionyl chloride; water; sodium hydroxide; In ethanol; water;