Technology Process of C16H20BrNO2
There total 6 articles about C16H20BrNO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C11H12BrNO;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
for 2.5h;
Inert atmosphere;
pivaloyl chloride;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
With
ammonium chloride;
In
tetrahydrofuran; water; mineral oil;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / acetonitrile; water / 0.17 h / -5 °C
1.2: 20 °C
1.3: -5 °C / pH 2
2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / -5 °C / Inert atmosphere
3.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere
3.2: 2 h / -5 °C
4.1: toluene / 3 h / Reflux; Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / -5 - 20 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 20 °C / Inert atmosphere
6.2: 0 - 20 °C
With
dmap; sodium hydride; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene / 3 h / Reflux; Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / -5 - 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; mineral oil / 2.5 h / 0 - 20 °C / Inert atmosphere
3.2: 0 - 20 °C
With
sodium hydride; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; toluene; mineral oil;
